Heterogeneous Gold Nanoparticle-Based Catalysts for the Synthesis of Click-Derived Triazoles via the Azide-Alkyne Cycloaddition Reaction

A supported gold nanoparticle-catalyzed strategy has been utilized to promote a click chemistry reaction for the synthesis of 1,2,3-triazoles via azide-alkyne cycloaddition (AAC) reaction. While advent effective non-copper catalysts (i.e., Ru, Ag, Ir) demonstrated catalysis AAC reaction, additional robust catalytic systems complementary copper catalyzed remain in high demand. Herein, Au nanoparticles on Al2O3, Fe2O3, TiO2 and ZnO, along with reference (gold carbon titania supplied by World Gold Council) were used as The metal loadings 0.7–1.6% (w/w relative support) able selectively obtain 1,4-disubstituted-1,2,3-triazoles moderate yields up 79% after 15 min, under microwave irradiation at 150 °C using 0.5–1.0 mol% catalyst loading through one-pot three-component (terminal alkyne, organohalide sodium azide) procedure according “click” rules. Among catalysts, Au/TiO2 gave best results.